gastroplus version 9.5  (Simulations Plus Inc)

Journal: Frontiers in Pharmacology

Article Title: Microfluidic technology and simulation models in studying pharmacokinetics during pregnancy

doi: 10.3389/fphar.2023.1241815

Figure Lengend Snippet: Simulated pregnant pharmacokinetics of pravastatin. (A) Structure of pregnancy related PBPK model. Structure of Pregnancy PBPK was obtained from Gastroplus software. (B) Predicted pharmacokinetics of pravastatin concentrations in maternal plasma and amniotic fluid during different gestation ages. (C) Simulated pharmacokinetics of pravastatin in maternal plasma and comparison to nonpregnant population.

Article Snippet: All the modeling and simulations were conducted in GastroPlus™ (version 9.5, Simulations Plus, Inc., Lancaster, CA, United States), an In silico prediction tool for a comprehensive ADME description.

Techniques: Software

Journal: Pharmaceutics

Article Title: Optimized In Silico Modeling of Drug Absorption after Gastric Bypass: The Case of Metformin

doi: 10.3390/pharmaceutics13111873

Figure Lengend Snippet: Plasma concentration–time profile observed by Pentikäinen et al. (squares) and the predicted plasma concentration–time profile by GastroPlus TM (solid line) in a healthy subject.

Article Snippet: GastroPlus TM software (version 9.5 Simulations Plus, Inc., Lancaster, CA, USA) was used for gastrointestinal simulations of metformin absorption in healthy subjects, as well as subjects with obesity.

Techniques: Clinical Proteomics, Concentration Assay

Journal: Pharmaceutics

Article Title: Optimized In Silico Modeling of Drug Absorption after Gastric Bypass: The Case of Metformin

doi: 10.3390/pharmaceutics13111873

Figure Lengend Snippet: Regional gastrointestinal absorption predicted by GastroPlus TM in healthy human subjects following oral administration of 500 mg of metformin.

Article Snippet: GastroPlus TM software (version 9.5 Simulations Plus, Inc., Lancaster, CA, USA) was used for gastrointestinal simulations of metformin absorption in healthy subjects, as well as subjects with obesity.

Techniques:

Journal: Pharmaceutics

Article Title: Optimized In Silico Modeling of Drug Absorption after Gastric Bypass: The Case of Metformin

doi: 10.3390/pharmaceutics13111873

Figure Lengend Snippet: Plasma concentration–time profile observed by Padwal et al. (squares) and the predicted plasma concentration–time profile by GastroPlus TM (solid line) in the control subject (with obesity).

Article Snippet: GastroPlus TM software (version 9.5 Simulations Plus, Inc., Lancaster, CA, USA) was used for gastrointestinal simulations of metformin absorption in healthy subjects, as well as subjects with obesity.

Techniques: Clinical Proteomics, Concentration Assay, Control

Journal: Pharmaceutics

Article Title: Optimized In Silico Modeling of Drug Absorption after Gastric Bypass: The Case of Metformin

doi: 10.3390/pharmaceutics13111873

Figure Lengend Snippet: Plasma concentration–time profile observed by Padwal et al. (squares) and the predicted plasma concentration–time profile by GastroPlus TM (solid line) in the post-RYGB subject.

Article Snippet: GastroPlus TM software (version 9.5 Simulations Plus, Inc., Lancaster, CA, USA) was used for gastrointestinal simulations of metformin absorption in healthy subjects, as well as subjects with obesity.

Techniques: Clinical Proteomics, Concentration Assay

Journal: Pharmaceutics

Article Title: Optimized In Silico Modeling of Drug Absorption after Gastric Bypass: The Case of Metformin

doi: 10.3390/pharmaceutics13111873

Figure Lengend Snippet: Plasma concentration–time profile observed by Padwal et al. (squares) and the predicted plasma concentration–time profile by GastroPlus TM (solid line) in the post-RYGB subject with adjusted physiology.

Article Snippet: GastroPlus TM software (version 9.5 Simulations Plus, Inc., Lancaster, CA, USA) was used for gastrointestinal simulations of metformin absorption in healthy subjects, as well as subjects with obesity.

Techniques: Clinical Proteomics, Concentration Assay